Medicament Delivery Device

ABSTRACT

A medicament delivery device includes a generally elongated tubular housing having opposite proximal and distal parts; a needle shield sleeve slidably and coaxially arranged inside the housing with a proximal part of the sleeve protruding a distance outside the proximal part of the housing; a syringe carrier mechanism having a syringe carrier slidably and coaxially arranged within the needle shield sleeve, a syringe having a stopper, a medicament, and a needle, the syringe being coaxially arranged within the syringe carrier; and a holding member connected to the syringe carrier; a first activator member an a second activator member; a drive mechanism adapted to accumulate a drive force for moving the syringe carrier mechanism in a first step and a second step. The second activator member is arranged within an information device for producing audible, visual, and/or tactile feedback to a user about a completed injection.

TECHNICAL AREA

The present invention relates to a medicament delivery device and inparticular a device which is capable of providing information regardinga completed medicament delivery step.

BACKGROUND OF INVENTION

There are a number of devices on the market that are capable ofautomatically or semi-automatically delivering doses of medicament,where these devices comprise a number of inter-acting components forobtaining the desired functions.

One type of such delivery devices is an injector capable of deliveringdoses of medicament, having functions such as penetration of thepatient's skin and a subsequent injection of medicament. One such deviceis for example disclosed in the document EP 1349590, comprising anactivation mechanism in the form of a button placed at its distal end.The button may only activate the mechanism if the front end of thedevice is pressed against an injection site. When done so and the buttonis pressed, the penetration mechanism inside the injector is releasedwhereby the needle is pushed into the body of the patient. After this,the injection is performed.

When the injection is completed, the patient withdraws the injector withthe needle from the injection site, whereby a needle shield is pushedforward until it surrounds the needle and is then locked.

With an injector of the above described type there is often a desire forthe user to know when the injection is completed and it is safe toremove the injector. A few solutions of informing the user of the statusof the injection have been developed.

U.S. Pat. No. 6,221,046 describes an injection device having an “end ofinjection click: including an extension of a flexible tab of a dose dialmechanism. The tab with the extension falls into a groove in thehousing, causing an audible click at the end of injection. US2004/0097883 discloses a similar end of injection click solution.

However, even if some solutions have been presented regarding informinga user of a medical delivery device, there is still room forimprovements, especially regarding the delivering step of a medicaldelivery device.

BRIEF DESCRIPTION OF INVENTION

The aim of the present invention is to remedy the drawbacks of the stateof the art devices.

This aim is solved according to the present invention by a medicamentdelivery device according to the features of the independent patentclaim.

Preferable embodiments form the subject of the dependent patent claims.

According to a main aspect of the invention it is characterised by amedicament delivery device comprising a generally elongated tubularhousing having opposite proximal and distal parts; a needle shieldsleeve slidably and coaxially arranged inside the housing and wherein aproximal part of said sleeve protrudes a distance outside the proximalpart of the housing; a syringe carrier mechanism comprising a syringecarrier slidably and coaxially arranged within the needle shield sleeve,a syringe comprising a stopper, a medicament and a needle, wherein saidsyringe is coaxially arranged within said syringe carrier, and a holdingmember connected to the syringe carrier; a first activator memberslidably and coaxially arranged within the housing and connected to saidneedle shield sleeve; a second activator member slidably and coaxiallyarranged within the first activator member; a drive mechanism slidablyand coaxially arranged within the second activator member and releasiblyconnected to the holding member and to the second activator

member, wherein said drive mechanism is adapted to accumulate a driveforce for moving said syringe carrier mechanism in a first step forpenetrating the needle into an injection site and to move said stopperin a second step for expelling the medicament through the needle, andwherein said drive mechanism is controlled by the first and the secondactivator members; wherein said second activator member is arranged withinformation means arranged to cooperate with corresponding interactingmeans arranged on the distal part of the elongated tubular housing afterthe medicament is completely expelled such that a remaining drive forceof the accumulated drive force in the drive mechanism forces the secondactivator member to be displaced towards the distal part of theelongated tubular housing for producing audible, visual and/or tactilefeedback to a user about a completed injection.

According to another aspect of the invention, said information meanscomprises an information member attached to a distal transversal endwall of the second activator member, and said corresponding interactingmeans comprises an opening arranged on a distal wall of the distal partof the elongated tubular housing.

According to a further aspect of the invention, said information memberis provided with a characteristic colour.

According to yet another aspect of the invention, the drive mechanismcomprises a plunger rod arranged to act on the stopper inside saidsyringe, and a pre-tensioned first compression spring having a forcecapable of urging said plunger rod to move in a first step said syringecarrier mechanism for penetrating the needle into an injection site andin a second step said stopper for expelling the medicament through theneedle.

According to another aspect of the invention, the plunger rod isslidably and coaxially arranged within the second activator member andthe pre-tensioned first compression spring is coaxially arranged withinthe plunger rod between a proximal end wall of the plunger rod and thedistal transversal end wall of the second activator member.

According to a further aspect of the invention, the second activatormember comprises flexible tongues having annular inwardly directedledges, wherein the holding member comprises flexible tongues havingannular inwardly directed ledges, and wherein the plunger rod comprisesa circumferential groove having a mutual shape as that of the ledges ofthe second activator member and as that of the ledges of the holdingmember so that the annular inwardly directed ledges of the secondactivator member and the radial inwardly directed ledges of the holdingmember fit into the groove.

According to yet another aspect of the invention, the plunger rodarranged to be held against the force of the pre-tensioned firstcompression spring by the inwardly directed ledges of the tongues of thesecond activator member situated in the groove of the plunger rod, andby the first activator member which surrounds and prevents the tonguesfrom moving radially outwards.

According to another aspect of the invention, the device furthercomprises a pre-tensioned second compression spring having an annularproximal end resting on a second annular ring of the first activatormember and an annular distal end resting on the proximal surface of stopledges of the second activator member.

According to a further aspect of the invention, the needle shield sleeveand the first activator member connected to it are arranged to be movedcoaxially and distally in relation to the housing and to the secondactivator member when the proximal part of said needle shield sleeve ispressed against the injection site for allowing the inwardly directedledges of the tongues of the second activator member to be released fromthe groove of the plunger rod, such that the force form thepre-tensioned first compression spring urges said plunger rod to move ina first step said syringe carrier mechanism and in a second step saidstopper.

According to yet another aspect of the invention, the second activatormember is arranged to be coaxially and distally moved by a remainingforce of the pre-tensioned first compression spring after the distal endof the plunger rod pass the ledges of the second activator member suchthat the tongues are radially moved inwards, whereby the distaltransversal end wall of the second activator member strikes against adistal wall of the distal housing part giving an audible signalindicating that the injection has been completed and that the device canbe safely removed from the injection site.

According to another aspect of the invention, said information memberprotrudes trough said opening becoming tactile and/or visible to providetactile and/or visual information indicating that the injection has beencompleted and that the device can be safely removed from the injectionsite when the second activator member is coaxially and distally moved.

According to a further aspect of the invention, the needle shield sleeveand the first activator member are arranged to be coaxially andproximally moved in relation to the housing and to the second activatormember by a force from the pre-tensioned second compression springacting on the first activator member and thus on the needle shieldconnected to it for covering the needle, when the proximal part of theneedle shield sleeve is removed from the delivery site.

According to yet an aspect of the invention, the first activator membercomprises ribs on its inner surface arranged to interact with aband-shaped part of the second activator member after the needle shieldsleeve and the first activator member are coaxially and proximallymoved, for preventing any attempts to push the needle shield sleevedistally into the device.

There are a number of advantages with the present invention. Because theuser is provided with information regarding the completed injection,he/she can safely remove, the medicament delivery device from thedelivery site, knowing that the injection is completed.

An advantage is that the remaining force of the compression spring meansused for penetration and injection is used for providing the informationto the user.

In this aspect the information could be visual, i.e. that the user canactually see that the injection has been performed through an opening inthe device, like a window or a passage. Further in order to enhance thevisibility the indicator could have a bright and/or different colourthan the rest of the device.

Further the information member could also be made to protrude throughthe housing of the device, thereby also providing tactile information tothe user as well as visible.

In addition to the visual and/or tactile information the deviceaccording to the invention could be audible in that there is a distinctsound when the injection has been performed.

A preferable arrangement of the information member is arranged at thedistal end of the device, which facilitates the design since it does notrequire any more components than the second activator member in order toprovide an information function.

In all several ways of positively indicating the performed injection isobtained with the present invention.

These and other aspects of, and advantages with, the present inventionwill become apparent from the following detailed description of theinvention and from the accompanying drawings.

BRIEF DESCRIPTION OF DRAWINGS

In the following detailed description of the invention, reference willbe made to the accompanying drawings, of which

FIGS. Ia, b show cross-sectional side views of a medicament deliverydevice according to the present invention, where FIG. Ib is taken 90° inrelation to FIG. Ia;

FIG. 2 is an exploded view of the medicament delivery device of FIG. 1,and

FIGS. 3-6 are cross-sectional side views of the medicament deliverydevice according to the present invention in different functionalstates.

DETAILED DESCRIPTION OF THE INVENTION

In the present application, the term “distal part/end” refers to thepart/end of the device, or the parts/ends of the members thereof, whichunder use of the device, is located the furthest away from a deliverysite of a patient. Correspondingly, the term “proximal part/end” refersto the part/end of the device, or the parts/ends of the members thereof,which under use of the device is located closest to the delivery site ofthe patient.

The medicament delivery device, e.g. an auto-injector as seen in FIG. 1,comprises a generally elongated tubular housing having opposite proximal10 and distal 12 parts. The proximal housing part 10 is arranged withelongated openings 14 for viewing a syringe 16 which contains a liquidmedicament, FIG. 2. The distal part is arranged with engagement means asannular recesses e.g. on its inner surface adapted to interface withcorresponding engagement means on e.g. the proximal outer surface of theproximal part.

The device further comprises a needle shield sleeve 20, FIG. 2,hereinafter named needle shield, wherein said needle shield comprises aproximal part 22 having a certain diameter and a distal part 24 having adiameter larger than the proximal part, where these parts are joined byan intermediate conical part 26, FIG. 2. Two elongated grooves 28 arearranged along the needle shield, on opposite sides of the needleshield, also for viewing the syringe 16, FIG. 2. On the inner surface ofthe conical part 26, a circumferential ledge 30 is arranged, FIG. 2. Atthe distal end of the needle shield two openings 32 are arrangedopposite each other, where each opening is arranged with a somewhatinwardly projecting, flexible, tongue 34, FIG. 2. The needle shieldsleeve 20 is slidably and coaxially arranged inside the housing and theproximal part of said sleeve protrudes a distance outside the proximalpart of the housing.

The device also comprises a syringe carrier mechanism comprising asyringe carrier 36 slidably and coaxially arranged within the needleshield sleeve; the syringe 16 comprising a stopper 92, the medicamentand a needle, wherein said syringe is coaxially arranged within saidsyringe carrier; and a holding member 46 connected to the syringecarrier.

The syringe carrier 36 has the form of a general tubular body and theproximal part of the syringe carrier is arranged with a neck portion 38of lesser diameter, FIG. 2 Adjacent the neck portion cut-outs have beenmade on either side to form guide surfaces 39. These surfaces cooperatewith corresponding shapes of the inner surface of the needle shield inorder to obtain a stop mechanism against rotation of the syringe carrierrelative the needle shield. The distal end of the syringe carrier isarranged with two distally extending tongues 40, where each tongue isarranged with an opening 42 and an inwardly directed ledge on the distaledge of each opening, FIG. 2. The syringe carrier is further arrangedwith radial inwardly directed flanges on its inner surface in order toobtain a space between the syringe carrier wall and the syringe 16 to beplaced inside.

The holding member 46, FIG. 2, comprises a ring-shaped body 48 having anannular ledge 50 arranged around its circumference and a number offlexible tongues 52 directed towards the distal end of the device andwherein each tongue 52 is arranged with radial inwardly directed ledges54, FIG. 1 b.

The device also comprises a first activator member 56 which is slidablyand coaxially arranged within the housing and connected to the needleshield sleeve 20 as will be described below, which has a tubular shapeand which comprises a proximal end with a conical part 58 ending in aledge 60 on its outer surface, FIG. 2. At a distance from the ledge 60,a first annular ring 62 is arranged on the outer surface, FIG. 2. Asecond annular ring 64 is also arranged a further distance from theledge 60.

The device further comprises a second activator member 66 which isslidaby and coaxially arranged within the first activator member 56 andwhich has a mainly tubular shape. A number of longitudinally directedcut-outs 68 are arranged along the proximal outer surface of the secondactivator member so as to form flexible tongues 70, FIG. 2. The proximalend of each flexible tongue 70 has an inclined transition surface whichmeets with a band-shaped part 72 with enlarged diameter, FIG. 3. On theinner surface adjacent the transition surface, an annular inwardlydirected ledge 74 is arranged, FIG. 1 b. Further, the second activatormember 66 is arranged with information means arranged to cooperate withcorresponding interacting means arranged on the distal part of theelongated tubular housing. Said information means comprises aninformation member 78 attached to a distal transversal end wall 76 ofthe second activator member, and said corresponding interacting meanscomprises an opening 80 arranged on a distal wall 82 of the distal partof the elongated tubular housing, FIG. Ia.

The device also comprises a drive mechanism which is slidably andcoaxially arranged within the second activator member 66, and which isreleasibly connected to the holding member and to the second activatormember, said drive mechanism being controlled by the first and thesecond activator members as will be described below. The drive mechanismis adapted to accumulate a drive force for moving the syringe carriermechanism in a first and a second step and, after completely expellingthe medicament, to force the second activator member towards the distalpart of the elongated tubular housing for producing audible, visualand/or tactile feedback to a user about a completed injection.

The drive mechanism comprises a plunger rod 90 arranged to act on thestopper 92 inside said syringe 16, and a first compression spring 94that is pre-tensioned to have an accumulated force capable of urgingsaid plunger rod to move said syringe carrier mechanism in a first stepfor penetrating the needle into an injection site and to move saidstopper in a second stepfor expelling the medicament through the needle.The plunger rod is slidably and coaxially arranged within the secondactivator member and the pre-tensioned first compression spring 94 iscoaxially arranged within the plunger rod between a proximal end wall 98of the plunger rod and the distal transversal end wall 76 of the secondactivator member. Further a guide rod 100 is arranged inside the firstcompression spring 94, FIG. 1 a.

The plunger rod 90 is formed as a tube with an outer diameter somewhatsmaller than the inner diameter of the syringe body to be used. Theplunger rod 90 is arranged with a circumferential groove 96 having amutual shape as that of the ledges 74 of the second activator member 66and as that of the ledges 54 of the holding member 46 so that theannular inwardly directed ledges 74 of the second activator member 66and the radial inwardly directed ledges 54 of the holding member 46 fitinto the groove 96, FIG. 1 b.

The device further comprises a pre-tensioned second compression spring102 having an annular proximal end resting on the second annular ring 64of the first activator member 56 and an annular distal end resting onthe proximal surface of stop ledges 104 of the second activator member66, FIG. 2.

The function of the device according to the invention will now bedescribed in connection with the FIGS. 3-6.

When the device is assembled, the distal housing part 12 is fixedlyattached to proximal housing part by suitable engagement means formingthe elongated tubular housing and the first and the second activatormembers are coaxially movable relative each other. However, when thedevice is in a non-activation position, the plunger is held against theaccumulated force of the pre-tensioned first compression spring 94 bythe inwardly directed ledges 74 of the tongues 70 of the secondactivator member 66 situated in the groove 96 of the plunger 90, and bythe first activator member 56 which surrounds and prevents the tongues70 from moving radially outwards. Further the ledges 54 of the holdingmember 46 are also arranged in the groove 96, FIG. 1 b. The inwardlydirected ledges on the distal edge of each opening 42 of the syringecarrier 36 pass the distal end surface of the annular ledge 50 of theholding member 46 for connecting the syringe carrier to the holdingmember, and at the same time the tongues 34 of the needle shield 20 fitthe distal surface of the ledge 60 of the first activator member 56 forconnecting the needle shield to the first activator member.

The needle shield sleeve and the first activator member connected to itare arranged to be moved coaxially and distally in relation to thehousing and to the second activator member against the force of thepre-tensioned second compression spring 102, when the proximal part ofsaid needle shield sleeve is pressed against the injection site, FIG. 3.When the first activator member moves distally, the band-shaped part 72of the second activator comes out from the surrounding of the firstactivator member 56, FIG. 3 and the resilient properties of the tongues70 of the activator means allows the proximal end of the tongues 70 toflex radially outwards, causing the ledges 74 to be released from thegroove 96 of the plunger rod 90. However, the ledges 54 of the holdingmember 46 are still in the groove 96 of the plunger rod and with theproximal end surface against the distal end of the syringe carrier 36,whereby the accumulated force from the pre-tensioned first compressionspring urges said plunger rod to move in the first step said syringecarrier mechanism, whereby a penetration of the needle into theinjection site is performed.

When the syringe carrier has reached its most proximal position it isforced to a stop. However the accumulated force of the pre-tensionedfirst compression spring acting on the plunger rod is so high that theledges 54 of the holding member 46 are forced out of the groove of theplunger rod.

The accumulated force from the pre-tensioned first compression springcontinues to urge said plunger rod to move in the second step saidstopper inside the syringe and the liquid medicament is injected intothe patient until the stopper reaches the inner proximal end of thesyringe, FIG. 4. After the liquid medicament has been injected and thedistal end of the plunger rod has passed the ledges 74 of the secondactivator member 66, the tongues 70 are radially moved inwards. Becausethe pre-tensioned first compression spring is also acting on the innersurface of the distal transversal end wall 76 of the second activatormember 66 and has a remaining accumulated force, the second activatormember 66 is moved distally until the outer surface of the distaltransversal end wall 76 of the second activator member 66 strikesagainst the inner surface of the distal wall 82 of the distal housingpart 12 giving an audible signal to the patient indicating that thedelivery e.g. the injection has been completed and that the device canbe safely removed from the injection site, FIG. 5.

Further, the protrusion 78 of the second activator member 66 protrudesthrough the opening 80 becoming tactile and/or visible to providetactile and/or visual information indicating that the injection has beencompleted, FIG. 5, and that the device can be safely removed from theinjection site when the second activator member is coaxially anddistally moved, e.g. if for instance the users finger is positioned onthe end wall 82 and in addition a visual indication in that theprotrusion 78 is visible through the passage 82. In order to enhance thevisibility, the protrusion could be arranged with a bright colour,differing from the colour of the rest of the device.

The needle shield sleeve and the first activator member are arranged tobe coaxially and proximally moved in relation to the housing and to thesecond activator member by a force from the pre-tensioned secondcompression spring 102 acting on the first activator member and thus onthe needle shield connected to it for covering the needle, when theproximal part of the needle shield sleeve is removed from the deliverysite FIG. 6.

The first activator member 56 comprises ribs (not shown) on its innersurface arranged to interact with a band-shaped part 72 of the secondactivator member 66 after the needle shield sleeve and the firstactivator member are coaxially and proximally moved, for preventing anyattempts to push the needle shield sleeve distally into the device,which prevents unintentional needle sticks.

It is to be understood that the embodiment described above and shown inthe drawings is to be regarded only as a non-limiting example of theinvention band that it may be modified in many ways within the scope ofthe patent claims.

1-13. (canceled)
 14. Medicament delivery device comprising: a generallyelongated tubular housing having opposite proximal and distal parts; aneedle shield sleeve slidably and coaxially arranged inside the housingand wherein a proximal part of said needle shield sleeve protrudes adistance outside the proximal part of the housing; a syringe carriermechanism comprising a syringe carrier slidably and coaxially arrangedwithin the needle shield sleeve, a syringe comprising a stopper, amedicament and a needle, wherein said syringe is coaxially arrangedwithin said syringe carrier, and a holding member connected to thesyringe carrier; a first activator member slidably and coaxiallyarranged within the housing and connected to said needle shield sleeve;a second activator member slidably and coaxially arranged within thefirst activator member; a drive mechanism slidably and coaxiallyarranged within the second activator member and releasibly connected tothe holding member and to the second activator member, wherein the drivemechanism comprises a plunger rod arranged to act on the stopper insidesaid syringe, wherein the plunger rod is slidably and coaxially arrangedwithin the second activator member; wherein the second activator membercomprises flexible tongues having annular inwardly directed ledges,wherein the holding member comprises flexible tongues having annularinwardly directed ledges, and wherein the plunger rod comprises acircumferential groove having a mutual shape as that of the ledges ofthe second activator member and as that of the ledges of the holdingmember so that the annular inwardly directed ledges of the secondactivator member and the radial inwardly directed ledges of the holdingmember fit into the groove.
 15. The medicament delivery device of claim14, wherein said second activator member comprises a number oflongitudinally directed cut-outs being arranged along the proximal outersurface of the second activator member so as to form said flexibletongues, wherein the proximal end of each flexible tongue has aninclined transition surface which meets with a band-shaped part withenlarged diameter, wherein said annular inwardly directed ledge arearranged on the inner surface adjacent the transition surface.
 16. Themedicament delivery device of claim 14, wherein said first activatormember comprises a proximal end with a conical part ending in a ledge onits outer surface, wherein at a distance from the ledge, a first annularring is arranged on the outer surface, and a second annular ring is alsoarranged a further distance from the ledge.
 17. The medicament deliverydevice of claim 15, wherein when the first activator member movesdistally during use of the medicament delivery device, the band-shapedpart of the second activator member comes out from the surrounding ofthe first activator member, and the resilient properties of the flexibletongues of said second activator member allows the proximal end of thetongues to flex radially outwards, causing the ledges to be releasedfrom the groove of the plunger rod.
 18. The medicament delivery deviceof claim 15, wherein the first activator member comprises ribs on itsinner surface arranged to interact with said band-shaped part of saidsecond activator member after the needle shield sleeve and the firstactivator member are coaxially and proximally moved, for preventing anyattempts to push the needle shield sleeve distally into the device. 19.The medicament delivery device of claim 14, wherein said drive mechanismis adapted to accumulate a drive force for moving said syringe carriermechanism in a first step for penetrating the needle into an injectionsite and to move said stopper in a second step for expelling themedicament through the needle, and wherein said drive mechanism iscontrolled by the first and the second activator members.
 20. Themedicament delivery device of claim 14, wherein the drive mechanismcomprises a pre-tensioned first compression spring having a forcecapable of urging said plunger rod to move in a first step said syringecarrier mechanism for penetrating the needle into an injection site andin a second step said stopper for expelling the medicament through theneedle.
 21. The medicament delivery device of claim 20, wherein thepre-tensioned first compression spring is coaxially arranged within theplunger rod between a proximal end wall of the plunger rod and thedistal transversal end wall of the second activator member.
 22. Themedicament delivery device according to claim 21, wherein the plungerrod is arranged to be held against the force of the pre-tensioned firstcompression spring by the inwardly directed ledges of the tongues of thesecond activator member situated in the groove of the plunger rod, andby the first activator member which surrounds and prevents the tonguesfrom moving radially outwards.
 23. The medicament delivery deviceaccording to claim 22, wherein it further comprises a pre-tensionedsecond compression spring having an annular proximal end resting on asecond annular ring of the first activator member and an annular distalend resting on the proximal surface of stop ledges of the secondactivator member.
 24. The medicament delivery device according to claim23, wherein the needle shield sleeve and the first activator memberconnected to it are arranged to be moved coaxially and distally inrelation to the housing and to the second activator member when theproximal part of said needle shield sleeve is pressed against theinjection site for allowing the inwardly directed ledges of the tonguesof the second activator member to be released from the groove of theplunger rod, such that the force from the pre-tensioned firstcompression spring urges said plunger rod to move in a first step saidsyringe carrier mechanism and in a second step said stopper.
 25. Themedicament delivery device of claim 14, wherein said second activatormember is arranged with information means arranged to cooperate withcorresponding interacting means arranged on the distal part of theelongated tubular housing after the medicament is expelled such that aremaining drive force of the accumulated drive force in the drivemechanism forces the second activator member to be displaced towards thedistal part of the elongated tubular housing for producing audible,visual and/or tactile feedback to a user about a completed injection.26. The medicament delivery device of claim 14 wherein the medicamentdevice comprises an autoinjector.
 27. The medicament delivery device ofclaim 14 wherein the generally elongated tubular housing comprises atleast one elongated opening for viewing the syringe.
 28. The medicamentdelivery device of claim 14 wherein the proximal part of the needleshield comprises a first diameter and a distal part of the needle shieldcomprising a second diameter wherein the first diameter of the proximalpart is different than the second diameter of the distal part.
 29. Themedicament delivery device of claim 14 wherein the syringe carriercomprises a tubular body having a first diameter and a proximal part ofthe syringe carrier comprising a neck portion comprising a seconddiameter, the second diameter of the neck portion different than thefirst diameter of the tubular body.
 30. The medicament delivery deviceof claim 14 wherein the syringe carrier comprises at least one guidesurface that cooperates with an inner surface of the needle shield inorder to provide a stop mechanism against rotation of the syringecarrier in relation to the needle shield.
 31. The medicament deliverydevice of claim 14 wherein the syringe carrier further comprises aplurality of inwardly directed flanges on an inner surface such that aspace is obtained between the syringe carrier and the syringe.
 32. Themedicament delivery device of claim 14, further comprising a guide rod.33. The medicament delivery device of claim 32, wherein the guide rod isarranged inside the first compression spring and is configured to guidethe plunger rod.